By W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg (eds.)
The First Adalat Symposium held in Tokyo in 1973, offered vital experimental and medical effects which were gathered in Europe and Japan with the recent coronary healing agent. the ecu scientists had a chance to debate the issues and effects for my part with their eastern colleagues. the second one Adalat Symposium was once held in Amsterdam inside a yr with the aim of bringing jointly quite often scientists inside Europe. the consequences mentioned in Tokyo were prolonged and supplemented via extra studies. Contributions in simple technological know-how are provided, yet most vital are these medical reviews, which aid and expand facts of the drug's efficacy in people. The editors desire to exhibit their appreciation to all these answerable for contributing to this file and, particularly, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. ok. BRANDAU for his or her editorial support, and to Dr. W. BOTTGER for the practise of the topic Index. we are hoping that this book may be a helpful contribution towards conveying info to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents advent: W. LOCHNER current foundation of Coronary treatment: W. LOCHNER. With eleven Figures 2 consultation I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and ok. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With eight Figures 12 dialogue comments 19 The Chemistry of Nifedipine: F. BOSSERT. With nine Figures 20 Pharmacokinetics of Adalat in Animal Experiments: okay. PATZSCHKE, B.
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Kg) 1 2 Ib 2b 6 5 4 5 4 5 1 2 1 5 5 2 1 2 4 0 0 0 0 0 1 0 0 0 0 0 0 2 4 2 4 0 0 0 0 0 0 5 0 0 0 0 1, before vagotomy and stellectomy. 2, after vagotomy and stellectomy. a Intravenous dose causing about 100% increase in the coronary sinus outflow. b Different animals. - Not examined. --l ________L __ ----L----J Y---' f!! 200 ~ III E Q) E ·.... --_~. 5. Dose-effect curves of dipyridamole and dilazep on the A-V conduction time and the FRP. Solid or open circles connected with continuous lines refer to the results obtained before vagotomy and stellectomy and those connected with broken lines were obtained after vagotomy and stellectomy in the same animals.
Diltiazem produced the second-degree block of A-V conduction in 2 of 5 dogs before and in all 4 dogs after vagotomy and stellectomy (Table 1). However, A-V conduction was resumed in about 5 min before, and in about 20 min after vagotomy and stellectomy. 3. v. (BRETSCHNEIDER et ai. 5 and Table 1). , approximately CFEDlOO (HENSEL et al. ), had virtually no detrimental effect on A-V conduction. , dilazep failed to produce the second-degree block of A-V conduction although it increased both the A-V conduction time and the FRP by about 20 msec (Fig.
During this period whole-body autoradiography did not reveal a higher concentration in any of the other tissues. Therefore it may be concluded that there is no evidence of a selective storage of nifedipine and its metabolites in any of the organs. In experiments on dogs, 1 mg/kg nifedipine- 14 C was administered orally. The dogs of group A received gelatin capsules containing the labelled compound in a formulation identical to that used in clinical trials. Group B received gelatin capsules containing the crystalline compound.