By Peter S. Harper

An eminent geneticist, veteran writer, OMMG sequence Editor, and famous archivist, Peter Harper offers a full of life account of the way our principles and information approximately human genetics have built over the last century from the viewpoint of somebody contained in the box with a deep curiosity in its old elements. Dr. Harper has researched the heritage of genetics and has had own touch with a number of key figures whose stories and reviews expand again 50 years, and he has interviewed and recorded conversations with lots of those vital geneticists. hence, instead of being a traditional historical past, this booklet transmits the essence of the tips and the folks concerned and the way they interacted in advancing- and infrequently retarding- the sphere. From the origins of human genetics; throughout the contributions of Darwin, Mendel, and different giants; the identity of the 1st human chromosome abnormalities; and up throughout the crowning glory of the Human Genome venture, this Short History is written within the author's attribute transparent and private type, which appeals to geneticists and to all these attracted to the tale of human genetics.

Show description

Read Online or Download A Short History of Medical Genetics PDF

Best special topics books

In the Grip of Disease: Studies in the Greek Imagination

This unique and vigorous e-book makes use of texts from historic drugs, epic, lyric, tragedy, historiography, philosophy, and faith to discover the effect of Greek rules on health and wellbeing and affliction on Greek idea. primary matters are deeply implicated: causation and accountability, purification and pollutants, the mind-body courting and gender variations, authority and the professional, fact and appearances, strong executive, and solid and evil themselves.

Emergent Computation: Emphasizing Bioinformatics (Biological and Medical Physics, Biomedical Engineering)

Emergent Computation emphasizes the interrelationship of different periods of languages studied in mathematical linguistics (regular, context-free, context-sensitive, and kind zero) with facets to the biochemistry of DNA, RNA, and proteins. furthermore, features of sequential machines akin to parity checking and semi-groups are prolonged to the research of the Biochemistry of DNA, RNA, and proteins.

Antioxidants in Science, Technology, Medicine and Nutrition

Using antioxidants is frequent in the course of the rubber, plastics, foodstuff, oil and pharmaceutical industries. This publication brings jointly info generated from examine in particularly separate fields of biochemical technological know-how and expertise, and integrates it on a foundation of the typical mechanisms of peroxidation and antioxidant motion.

Paracelsus: An Introduction to Philosophical Medicine in the Era of the Renaissance

A Karger 'Publishing Highlights 1890–2015' identify This 2d, revised version remains to be the reference paintings to be had in print and electronically on Paracelsus via the Paracelsus authority. moreover, it makes an excellent learn. See additionally Pagel's final e-book The Smiling Spleen on Paracelsianism as a old phenomenon.

Additional info for A Short History of Medical Genetics

Example text

The answer to Darwin’s problem lay, of course, in the work of Mendel, already published two years before Variation of Animals and Plants under Domestication appeared. Mendel’s particulate system of inheritance would have immediately shown Darwin how variation can be preserved intact through the generations, despite the apparent loss of its effects in the initial generation after crossing. But Darwin, like the rest of the world, remained unaware of Mendel’s work, so the key to the solution remained unrecognized for another 30 years.

In two short papers released in 1888, he essentially demolished the factual basis of Lamarckism, showing, first for plants and then for animals, how weak the evidence was and how implausible were any mechanisms by which environmental factors could affect the germ line. It is fair to say that Lamarckian inheritance of acquired characters never recovered scientifically from Weismann’s critique. His second paper included an assessment of human “mutilations,” including circumcision, body piercing, and foot binding; he concluded that there was no convincing evidence that any of these acquired characters had an effect on descendants.

The history of mankind, would it be too bold to imagine, that all warmblooded animals have arisen from one living filament, which THE GREAT FIRST CAUSE endued with animality, with the power of acquiring new parts, attended with new propensities, directed by irritations, sensations, volitions, and associations; and thus possessing the faculty of continuing to improve by its own inherent activity, and of delivering down those improvements by generation to its posterity, world without end! Erasmus Darwin’s concept of evolution is seen even more strikingly in his last work, The Temple of Nature, published in 1803 after his death: Organic Life beneath the shoreless waves Was born and nurs’d in Ocean’s pearly caves; First forms minute, unseen by spheric glass, Move on the mud, or pierce the watery mass; These, as successive generations bloom, New powers acquire, and larger limbs assume; Whence countless groups of vegetation spring, And breathing realms of fin, and feet, and wing.

Download PDF sample

Rated 4.54 of 5 – based on 30 votes