By Dr. R. Martínez, J. Vaquero, L. V. De La Morena, F. Tendillo, P. Aragonés (auth.), Professor Edward R. Hitchcock, Prof. Dr. Giovanni Broggi, Dr. Juan Burzaco, Dr. J. Martin-Rodriguez, Dr. Björn A. Meyerson, Dr. Szabolcs Tóth (eds.)

The ebook supplies the main up to date info for the increasing box of stereotactic and sensible neurosurgery from eu and foreign specialists. the latest advancements in neural transplantation and stereotactic irradiation are incorporated including the experiences on huge trials of analgesic surgical procedure and new ideas utilized in the therapy of various useful disorders.

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Additional info for Advances in Stereotactic and Functional Neurosurgery 9: Proceedings of the 9th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Malaga 1990

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No significant variation was found in the clinical efficacy from 6 to 12 months postoperatively. Immediately after operation the drugs were withheld, but in one of five patients who were receiving their postoperative Madopar 1500mg/day compared with 750mg/day by the end of 3 months after operation parkinsonian symptoms reappeared. Two of twelve patients who were intolerant and unresponsive to the drug developed, or were unable to continue taking the drug because of severe side effects got satisfactory response to Madopar 500-750 mg/day.

The disease is manifest by four major signs, tremor, cogwheel rigidity, akinesia, and loss of postural or balance reflexes. L-Dopa administration is the most favourable and effective treatment of PD in the last twenty years. However, when L-Dopa treatment is extended over long periods such as five to seven years, unfavourable dyskinesia or severe gastrointestinal side effects often appear. In recent years, brain transplantation of DA secreting cells has become one of the promising methods for repairing disturbance in DA metabolism both in basic neuroscience research as well as in clinical practice.

Implantation Procedures A variety of different procedures have been adopted, but fall into two main classes: "Solid" transplants. Pieces of donor tissue are inserted as a chunk or small fragments into the depths of the brain. For this to work the graft must be placed into a richly vascularised site that can provide adequate energy and nutrients to sustain the graft tissue. The lateral ventricles provide a natural site since the space is available and the choroid plexus provides a rich blood supply.

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